Business Joint Venture Opportunities in Manlius

- We have five in-house scientific projects: 1) An exosome-based delivery system for the transport, delivery, and localization of therapeutic molecules within the skin tumor microenvironment to treat human skin cancer. 2) The development of a confocal virtual reality (VR) 3-dimensional (3-D) immersive system for the diagnosis and analyses of human skin cancer tumors. 3) A skin cancer patient blockchain whereby skin cancer patients can set up smart contracts & receive payment for the use of their data from drug companies, research institutes, medical device companies, etc. 4) The utilization of ML and AI to visualize and analyze the resultant data from skin cancer subjects for the benefit of skin cancer patients, their family, and their healthcare providers. 5) The development of an in vitro toxicology system that uses human umbilical cord- and placental- derived mesenchymal stem cells, and cell lineages that may be derived from these, to serve as a developmental toxicological tool to reduce the number of animals use in preclinical drug research. - The company also works with pharmaceutical and diagnostic companies, research institutes, CROs, and CDMOs to help them develop molecular bioassays and digital pathology products, and to visualize and analyze the resultant data via AI and ML for the benefit of patients, their family, and their healthcare providers. - Currently, we have 3 clients: Klotho Therapeutics Inc. (a biotechnology company in San Diego, CA, USA), Unger Medical PC (a hair restoration medical practice in NY, NY, USA), and Astrix Technology Group (a life sciences strategy, technology, and staffing services company based in Red Bank, NJ, USA). • Target Market: - The business is specialized in developing diagnostics and therapeutics for human basal cell carcinoma, squamous cell carcinoma, and melanoma. This skin cancer group comprises the most diagnosed cancers worldwide of all cancer types with over five million cases diagnosed each year. - The skin cancer therapeutics diagnostics and therapeutics products industry worldwide were worth $8.2 billion USD in 2019 and is projected to reach $15 billion by 2027. This represents a CAGR of 7.5%. - What share of the total skin cancer target market is realistic for us to obtain? A conservative estimate is that our company should be able to reach $150 million USD in annual revenues by the close of 2028. • Problem or Need: - The main project involves the development of a Skin Cancer Patient Data Blockchain. - Currently there is a serious problem concerning how oncology patients organize and share their medical data, how companies get access to this data, and a lack of return in value to the patients for sharing their personal data. The blockchain is designed to tackle and solve these problems. - The blockchain for skin cancer patients will be comprised of multiple decentralized nodes contributing data to a shared ledger where patients can set up smart contracts to share and control their data. - Skin cancer patients will be able to share their data with research institutions, drug companies, diagnostic companies, contract research organizations, client trials organizers, and other stakeholders. - Also, planning to launch a medium of exchange within the blockchain system to allow patients to be given money for participation in the sharing of their data with the mentioned company stakeholders. - Therefore, the company stakeholders that plan to utilize the patient’s data would provide revenues and income to support the operations of the blockchain. - For example, pharmaceutical companies would be important customers that the business would cultivate as users of the patient’s healthcare data. This is because pharma companies can use this blockchain to discover patients with the right profile for a skin cancer clinical trial, even if those patients were not actively searching to participate in a clinical trial for a product from which the pharma or diagnostics company might benefit. This should greatly streamline for the pharma company the time it takes to enroll the right patients into clinical trials and get them started. • Solution: - What is the core value proposition? For the company stakeholders in the skin cancer patient blockchain, the business is hoping to demonstrate that this blockchain technology will be a way to improve business outcomes through better efficiency, risk management, and security. - For these customers, this will enable them to maintain and capture new sources of profit. At the same time, company stakeholder participation will also grow the business as the integrator and host of the blockchain and result in significant profit growth for the company. • Team: The team is comprised of: - Founder, President, and CEO, a 100% full-time permanent employee has a Ph. D. in Cell and Molecular Biology from St. John’s University (New York, NY), a M. S. in Microbiology & Immunology from Long Island University, and a M. B. A. from Le Moyne College. In addition, he has 20 years of quality assurance and regulatory affairs experience at the Bristol-Myers Squibb Company, Charles Rivers Laboratories, and Vybion, Inc. This includes moving numerous human therapeutic products from R&D, through clinical trials, and into the marketplace via approval by the US FDA and worldwide regulatory bodies. In addition to the above experience, Joseph has an addition 18 year of experience in human therapeutics research and development and in the management of laboratory-based cell culture, toxicological, or bioassay projects within the biopharmaceuticals industry. However, he is a Senior Member of the food, drugs & cosmetics section of the American Society for Quality (ASQ), and a society member of The American Association for the Advancement of Science (AAAS). - The President of Hillberg Consulting is a part-time, non-permanent hourly contract employee of R&D department. She is an accomplished executive and board member with a reputation for delivering bottom-line profitability while building the infrastructure to support growth and success. She has served at Johnson & Johnson Ortho Clinical Diagnostics as VP of R&D, and as Chief Technology Officer at Carestream Health. Holly has a B. S. in Chemical Engineering from Michigan Technology University and a M. S. in Electrical Engineering from Rochester Institute of Technology. - Marketing Consultant - part-time, non-permanent hourly employee. He is a professional engineer and entrepreneurial executive with a focus on emerging technology solutions applied to real world problems. He has substantial experience in team building and in developing market strategies & partnerships. This includes over two decades of technology & networks business planning, development, & implementation. He has a Masters in Entrepreneurial Studies - MIT Sloan School of Management, and M. S. & B. S. in Engineering from Syracuse U. and Utica College. - Blockchain Development Technical Project Management Consultant - Part-time, non-permanent hourly employee that is a contractor from EffectiveSoft Corporation, San Diego, CA. She has eight years of experience as VP of Service Delivery and as the Head of Sales for enterprise level software solutions at Effective Soft Corp. She has a M. B. A. from The University of Manchester and a B. S. degree from Minsk State Linguistics U. – Legal Counsel - Part-time, non-permanent hourly contract employee. He holds the Juris Doctor from Boston College Law School, and B. A. in Political Science from Binghamton University. He is a Partner at Newman & Lickstein, with eight years of experience in representing technology companies and investors in licensing, IP development, real estate, mergers & acquisitions, and business litigation. - Demonstrating results to stakeholders will be the key to success. For skin cancer, there is a lot of data collected from various heterogeneous sources – pathology imaging data, genetic testing, surgery, drugs intervention, payer, and insurance information, etc. - Some companies are using a website or app to meet the social needs of patients to discuss their concerns with other patients or a few qualified physicians. No competitor is comprehensively focusing on skin cancer data & treatment to the level that we do. Possible competitors have thus not yet integrated the patient data, shared consent, and the patient monetization blocks together into a comprehensive and workable blockchain system for skin cancer patients, or for any segment of the oncology market, for that matter. - This team, on the other hand, has decades of experience in oncology research, the development of products and services for cancer patients, in oncology clinical biomedicine and in oncology marketing, and that makes the company well-equipped to solve the problems around skin cancer patient data acquisition, its organization, and its beneficial use for the patients and for their healthcare providers. For example, regarding the latter, the company also harnesses artificial intelligence (AI) and machine learning (ML) to extract relevant data from the patient’s database that will help healthcare providers to better understand the patient’s tumor and the tumor microenvironment (i. e. , tumor growth, cellular migration, blood supply to the tumor, subcellular trafficking, and tumor metastasis), drug efficacy (including drug penetration into the tumor, possible tumor shrinkage or tumor death, and drug toxicity, and side effects), or the immediate or long term results of surgical intervention. - When competitors enter this specific market, the business plans to stand out by utilizing a value-based strategy that clearly displays our brand and the above competitive advantage. • Traction: - Currently works with pharmaceutical and diagnostic companies, research institutes, and contract research development and manufacturing companies to help them obtain and organize their molecular bioassays and pathology data. We propose to utilize this traction and intercompany personal connections to gain and grow customers that will use and pay for patient data on the blockchain. - Also use social media & patient advocacy organization to recommend the blockchain to skin cancer patients so that we can grow the patient database. - The company is also a member of the Hyperledger Foundation Healthcare Special Interest Group. Hyperledger, as part of the Linux Foundation, provides technology leaders with a uniquely open and collaborative international community from which to develop, validate, and field enterprise-grade blockchain technology solutions. It is the mandate of the Hyperledger Healthcare Special Interest Group (HC-SIG) to represent healthcare professionals and technologists, to globally unite these individuals, and to advance the state of the healthcare industry through the implementation of technology solutions using blockchain technologies in general, and the umbrella of Hyperledger frameworks and toolsets specifically. • Revenue Model: - Within the ecosystem surrounding the above patients, who would buy/lease the skin cancer blockchain services that the company wishes to market? In this blockchain system, individuals will be allowed to store and monetize their own health data including blood test results, medical history, genetic profile, skin photographs, pathology images and other sensitive information. - In the healthcare marketplace, cancer patients would be paid in stablecoin currency to lease their individual data to companies for a certain amount of time. - Pharmaceutical (pharma) companies would be important customers that the company would cultivate as users of the patient’s permitted healthcare data. - Blockchain can help pharma companies discover patients with the right profile for a clinical trial, even if those patients were not actively searching to participate in a clinical trial for a product from which the pharma or diagnostics company might benefit. - According to Milind Kamkolkar, chief data officer at Sanofi, patients could be prompted based on their data to join a clinical trial, thereby also accelerating the process and accuracy of trial recruitment. Using this blockchain if a person declines, no personal information will be shared, and the person's identity will remain private. If the person agrees, the overall process will move faster by abolishing the need for intermediaries. - For pharma companies, better inclusion in clinical trials and better reproducibility for studies can reduce the time and money needed to develop new drugs. - Besides pharma companies, research institutes will be willing to pay for the data from skin cancer patients, and the introduction of our blockchain-based data ecosystem may help ensure that the individuals take control over their data and companies and research institutions may acquire data more freely after the latter have obtained consent from individual patients. - How are the products and services going to generate revenue? The most straightforward way to generate revenue is to have the blockchain client customers pay for the products and services that exceed by a large margin what it costs to develop and operate the blockchain (a cost-plus strategy). - When competitors enter this specific market, plan to stand out by utilizing a value-based strategy that clearly displays the brand and competitive advantage. • Market Projections: - What share of the total skin cancer blockchain target market can we estimate is realistic for to obtain? The global skin cancer blockchain customer market size stood at USD 8.19 billion in 2019 and is projected to reach USD 14.55 billion by 2027, exhibiting a CAGR of 7.5% during the forecast period. A conservative estimate is that the company should be able to reach $150 million in annual revenues in 4 years. - These financial projections would be possible because of the company participating and partnering with individuals and companies within the oncology community to create superior value for the products and services. - Over the next 4 years, the company anticipates receiving funding from investors, and revenues from pharmaceutical companies and research institute customers. - However, expenditure are also expected to increase. Expenses incurred will be for the development of products and services, and for personnel, equipment, supplies, business development & marketing. • Competition: - We have identified Nebula Genomics and Longenesis as competitors. These two leading firms in artificial intelligence and blockchain technology for healthcare, are developing a platform for the storage and exchange of genomic data. - Nebula Genomics is a San Francisco-based biotechnical company that uses blockchain to “build a marketplace” for clinical genetics data. - Longenesis is a Hong Kong-based partnership between Insilico Medicine and the Bitfury Group, which makes blockchain platforms for the exchange of health data. - The above companies will reportedly apply artificial intelligence and blockchain technology to develop a platform for individuals and large data providers to store, manage, exchange, and profit from genomic and other types of clinical data. To automate data acquisition, the project developed by both Nebula Genomics and Longenesis will utilize smart contracts. - Unlike the Nebula Genomics and Longenesis blockchains, this blockchain project will be focused on oncology patients and the ecosystem around them rather than on a multitude of disease sectors. - In addition to Nebula Genomics and Longenesis, the U. S. -based life science research marketplace, Scientist. com, has revealed the development of a pharmaceuticals blockchain platform. This latter blockchain-powered platform is reportedly designed to track and protect pharmaceutical data. Thus, the Scientist. com DataSmart TM platform enables pharmaceutical and biotech companies to demonstrate that critical supplier information and important research data has not been tampered with and remains unaltered before submission to regulators such as the FDA and the EMEA. - However, the above platforms do not adequately address the pressing concerns of cancer patients regarding the control and sharing of their personal data. Competitive Advantage: • Strategy. Specifically for oncology blockchain products, the major company players that may join our blockchain to gain access to data from skin cancer patients include: Almirall S. A. Amgen, Inc. Boehringer Ingelheim GmbH. Bristol-Myers Squibb Company. Eli Lilly and Company. Elekta AB. F. Hoffmann-La Roche Ltd. GlaxoSmithKline plc. Merck & Co. , Inc. Mylan NV. Novartis AG. Pfizer. Regeneron. Sanofi. Sun Pharmaceutical Industries Ltd. Varian Medical Systems, Inc. Sensus Healthcare. ICAD, Inc. Accuray, Inc.

Coffee has always been the most important inherited herbal to accelerate the pace of life and modernization. The concept of Empire Coffee was born out of the Passion of the owners for coffee. The owners traveled across various countries investigating specialty coffee concepts. They felt the need for a premium specialty coffee house in Qatar that offers coffee made from organic. & unfertilized (no chemical additives) high-quality beans. With a unique taste that is attractive for various age groups. Empire Coffee is a first-of-its-kind specialty coffee company from Qatar, which was established in 2016. The concept was first tested as a small kiosk in the lobby of Ezdan Hotel – Al Dafna five years ago, which proved to be a success, and later in the same year, the business shifted from the hotel lobby and opened its first official outlet in the same building. Currently, there are 4 fully operational outlets that sell a variety of high-quality coffee, snacks, and specialized coffee machines and accessories for enthusiasts. The co-founders are currently in Doha, Qatar where the business is headquartered. We have no food trucks under our company as of now.

One Moto is an impact driven, multi-award-winning manufacturer of electric vehicles registered in London and headquartered in Dubai. We aim to provide sustainable, cost-effective, electrical transport solutions to service the first/last mile and food delivery. We cater to individuals as well as corporates. Have offices in UK, UAE, India, Sri Lanka, Chile, with another 14 countries in discussion. The micro-mobility industry is positioned to be USD 200-300 million in the next 10 years while the electric vehicle industry is expected to reach USD 22.1 billion in 3 years. Have sold hundreds of products so far and have received an order for 5,000 products that are currently being developed. The CEO of the business resides in UAE. The figures mentioned are the assumed and expected revenue that can be generated. The master distributor requires investment into a dedicated retail space (for dealerships). The distributor also has the opportunity to appoint sub-dealers.

Hades India Fashion aims for idealistic garments for the millennial culture to provide quality and satisfaction to all its customers. Hades in-house packaging exhibits class and elegance on the product inside, offering quality, finesse and resourceful packaging along with a product of high caliber. We are giving out sales partner opportunities to expand our brand reach across India. Hades Fashion Enterprises are manufacturers of 100% Premium Cotton Shirts made from high-grade yarn-dyed fabrics. We have a varied range of fabric collections ranging from Oxfords to Poplin to Broadcloth to Supima to Giza Cotton. We design the best of clothing per your requirements at genuine prices.

"I Love Babycakes" is a bakery running in Mumbai for 10 years and now launched in Hong Kong since January 2019. We specialize in cupcakes, teacakes, theme cakes, cookies, dessert jars, DIY baking kits. The bakery was started in Mumbai from a home kitchen in August 2009. We now have our own centralized commercial kitchen in Mumbai with a production capacity of over 1,500 cupcakes a day. We have retail presence in several prominent locations in Mumbai city. Other than supplying to cinemas we are also the official cake partners for the global kids theme park brand KidZania in Mumbai. We also take a number of personalized orders for baked products with many celebrity clients on our list. Other than this, we have our own online store and are present in various online food ordering platforms. We started the brand in Hong Kong in January of 2019 and it has seen a tremendous response with very quickly being listed as among the best cake brands in the city. We also conduct a host of baking classes regularly for children and adults alike at our kitchen in Hong Kong. We intend to take the brand "I Love Babycakes" to major cities in India and consequently outside of India to incorporate a cafe cum shared cloud kitchen model. The idea is to have a space with commercial kitchen equipment (with our brand name) where chefs and bakers can cook / bake and pay rent on an hourly basis to use. The space will also have an option for diners to come and dine on an all day dining menu. This space can also be rented out for baking / cooking classes to be hosted by the participating chefs where part of the proceeds will go to the owner. This model will allow self generating rents that can be used towards monthly operating expenses. Having run successfully in India for the last 10 years, we are now looking at using the franchising model to further our reach. We are looking at increasing our presence in major cities of India and across the globe following the above model. The goodwill of the Company and its popularity in Mumbai makes it an attractive choice. The freshness of the baked goods and the fun and creative nature of the brand makes it a brand of choice for interested franchisees.

Cone stands as a premium makeup brand rooted in the heart of Germany, renowned for its commitment to excellence and innovation. At the core of our brand is our state-of-the-art laboratory, where each of our products is meticulously developed, ensuring the highest quality standards. Leading the creative vision and product development is an esteemed lead makeup artist (MUA), whose expertise and passion serve as the cornerstone for the brand's innovative direction and vision. We are passionate about forging strong relationships with our partners and, as such, offer attractive discounts to resellers, distributors, and franchise partners. Our ambition is to establish a global network of committed partners capable of championing the Cone brand in their respective countries or regions. We invite you to join us in this exciting journey and become part of a brand that is set to redefine beauty standards around the world. We have a registration licence. The sale and EBITDA margin mentioned is what a franchise partner can expect to generate. These figures are estimated figures that have been derived based on market research.

Highly profitable and simple operation franchise model is here. The contract period is 10 years, with automatic renewal thereafter, providing long-term stability. Transparency regarding initial payments is evident, with a breakdown of franchise fees, security deposits, and training costs clearly specified. Low Minimum Self-Funding Requirement: An example of the minimum self-funding is 3 million yen, allowing for a relatively accessible investment for starting the business. Flexibility in Business Start-Up: The option to start in a small space, even with 7 seats, is feasible. With a simple operation requiring only one employee, there are minimal additional labor costs, making it a low-risk business model. Property Flexibility: The potential to attract customers in pre-existing or less popular locations is highlighted, reducing property-related costs compared to other franchises. Success Stories from Affiliated Stores: Successful franchise store records in Tokyo are presented, including clearly stated self-funding and annual income figures. Based on these achievements, the correlation between low initial investment and potential success is suggested. These factors, coupled with low investment costs, emphasize transparency and potential success for participants in the franchise.

Waaree Energies Limited was founded 35 years ago, with its headquarters in Mumbai, India. Waaree has India's largest aggregate installed capacity of 12GW as of last year at its plants in Chikhli, Surat, Tumb, and Nandigram in Gujarat and is a top player in the solar module export for this fiscal year. As of last year, the total number of Franchisee of Waaree was 407 in India and 20 outside India. The company has supplied more than 6GW of solar modules and commissioned more than 1.1GW solar EPC projects.

Eximso is a B2B cross-border e-commerce company located in Ernakulam, India. We started our operation in August of last year. During the period we learned what is the exact problem sellers and buyers face in a cross-border shipment. Finding genuine sellers and buyers is not an easy job. Even after that, the work is not going to be finished. We should deal with logistics, payment, customs clearance, etc. A procurement company helps industries get the right goods /services at the best price and a logistics company helps move goods from one place to another at the earliest. These two functions are correlated and one can’t stand alone. We Eximso came up here to make function both at the same time. We have a team of professionals with in-depth knowledge of sourcing and negotiating skills. Irrespective of the categories and volume of the materials, we do procurement and ship globally. Now customers can sell or buy goods as easily as in a local market through Eximso.

Kskin is Singapore’s #1 Korean express facial brand. With more than 50 outlets in Singapore alone and counting, as well as a presence in Malaysia and the Phillippines. In an industry saturated with aggressive sales tactics and packaged deals, our pay-per-visit business model is extremely popular with customers who want an effective facial but are afraid to step into traditional beauty salons for fear of hard selling by beauty consultants. "No Package", "No Appointment", and "Effective Results in 15 minutes" express facial service. Our unique approach combines pharmaceutical-grade skincare products and cutting-edge technology for efficient and remarkable results. Many testify to visible improvements in just 15 minutes! The average daily walk-ins per outlet is 30 people and the AOV ranges between SGD 50-100.

We help business owners run profitable 3D printing micro factories under the Virtual Factories brand. By joining our 'glocalized' network, operators gain access to our customer marketplace, helping us 're-shore' manufacturing. Virtual Factories is building a network of local 3D printing micro-factories to replace inefficient supply chains by reshoring manufacturing to North America. These localized 3D printing micro-factories produce parts and products ordered online through our marketplace. Virtual Factories return manufacturing and money to local communities.

We specialize in the manufacturing of hydraulic tubes and cylinders, pins and bushes, piston rods, pistons and head end covers, charging pumps, bearings, fabrication components, and many more. Our state-of-the-art facilities and skilled workforce ensure that our products meet the highest standards of quality and performance. We understand the critical role that spare parts play in the maintenance and repair of heavy equipment, which is why we are committed to providing our clients with reliable and durable spare parts that can withstand the toughest working conditions. Our products are designed to meet the specific requirements of each client, ensuring optimal performance and longevity. - We possess all the regulatory licenses required to run our operations like GST, UDYAM, and Import-Export.

The Magnat company works in the field of pre-sale and pre-lease preparation of real estate. Our business model consists precisely of the rapid pre-sale preparation of real estate for sale or rent. We spend 1-3 days to fully cosmetically prepare the property for sale. Our services include cleaning (general cleaning), window washing, garbage removal, small electrical and plumbing work, small tiling work, small painting or wallpaper work, dismantling of old equipment and furniture, small cosmetic decorations (plinths, curtains, baguettes, etc. ), professional photo-video. At the exit, our client receives a wonderful real estate object ready to be put up for sale. Our services increase the value of such real estate, and increase the number of people willing to buy it, as a result, the speed of sale increases by 3-10 times, and the cost by 10-20%. Many realtors cooperate with us because they are eager to cooperate with us and give us orders as well. We have a lot of clients, as our services are popular, they are 5-10 times cheaper than repairs, and faster, and this is exactly what people who want to quickly sell their real estate need - a low cost and a quick result. This is the key to our business model. The current partners are generating the mentioned revenue with the investment amount mentioned.

Dr Ice Enterprise is a diamond cutting group based in the UK, with sources of rough diamonds throughout the world. We cooperate with experienced diamond cutters & polishers, who will help you create the most beautiful cut diamonds. Our team of experts here at Dr Ice Enterprise Ltd provide quality valuations and appraisals of precious stones and metals. As proud members of several appraiser societies and organizations, we make sure to use the most up-to-date equipment so that you receive the highest quality certified diamond possible. Currently we have 2 stores one is in London and the other one in Dubai. The major operations are done from London, UK and the owner is from Dubai. By taking this franchise opportunity users is entering into eco friendly diamonds that have a vast need now worldwide and a lot of people are urging to invest in eco friendly diamonds now. The franchise partner will have to run a store and sell diamond and diamond jewelry.